Administration of 2-deoxy-D-glucose induces pyroptosis in murine breast cancer cells via cAMP/PKA/HK2 to impair tumor survival
These findings identified a novel metabolic-inflammatory axis (cAMP/PKA-HK2-caspase-3/GSDME) in breast cancer. Furthermore, study highlights the <i>in vivo</i> efficacy and safety of 2-DG and its ability to induce pyroptosis, thereby providing a basis for targeting drug resistance in breast cancer.
Authors
- Sha Jin
- Lin Li (ORCID: https://orcid.org/0000-0003-2934-650X)
- Kidong Eom (ORCID: https://orcid.org/0000-0001-5032-5311)
- Tingting Pan (ORCID: https://orcid.org/0000-0002-1673-6800)
- Wei Gao (ORCID: https://orcid.org/0000-0003-1335-0491)
- Jing Dong (ORCID: https://orcid.org/0000-0002-3684-2432)
Institutions
- Shenyang Agricultural University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Konkuk University (KR)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1724476
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00