Mechanistic role of CD82 palmitoylation in augmenting antitumor drug sensitivity via apoptosis regulation
Our findings reveal a novel role for CD82 palmitoylation in regulating drug-induced apoptosis. Disruption of palmitoylation potentiates chemotherapy-induced cell death, providing a molecular rationale for targeting CD82 palmitoylation as a combinatorial strategy to overcome therapeutic resistance in TNBC.
Authors
- W. Y. Han
- L Li
- Xinyu Yao (ORCID: https://orcid.org/0000-0002-9805-5485)
- Yihuan Zhang
- Ying Li (ORCID: https://orcid.org/0000-0003-3149-8457)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-0694-6409)
- Can Zhang (ORCID: https://orcid.org/0000-0003-3529-5438)
- Hongli Xu (ORCID: https://orcid.org/0000-0002-3304-2499)
- Sirui Chen (ORCID: https://orcid.org/0000-0001-9918-6850)
- Yaning Yu
- Shihao Wu (ORCID: https://orcid.org/0000-0003-0106-552X)
- Xue Gong (ORCID: https://orcid.org/0000-0003-0481-4119)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fonc.2025.1699420
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dalian Medical University