Thalamic metabolite changes after subthalamic nucleus deep brain stimulation in Parkinson’s disease: an exploratory magnetic resonance spectroscopy study
We present novel metabolite observations obtained through MRS in this exploratory study. Thalamic tNA concentrations in PD patients were comparable to those of healthy controls prior to surgery, but were significantly reduced following DBS implantation targeting the STN. These findings suggests the presence of a metabolite thalamic effect associated with DBS treatment.
Authors
- Peter Lundberg (ORCID: https://orcid.org/0000-0001-8661-2232)
- Anders Tisell (ORCID: https://orcid.org/0000-0003-0928-7282)
- Peter Zsigmond (ORCID: https://orcid.org/0000-0003-3982-7745)
- Sofie Tapper (ORCID: https://orcid.org/0000-0002-7809-2481)
- Nathanael Göransson
Institutions
- Linköping University (SE)
- Linköping University Hospital (SE)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fneur.2025.1662142
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00