Length of the Adult Human Colon in Health and Constipation Measured Using Magnetic Resonance Imaging
The study provides normative values of colon length, to which CC and IBS-C are compared. CC was associated with increased colon length and reduced capacity to elongate longitudinally, rather than radially, in response to a laxative challenge. Colon length in IBS-C was similar to HV. These measurements can improve our understanding of gut disease pathophysiology and response to treatment.
Authors
- Alex Menys (ORCID: https://orcid.org/0000-0001-6088-0730)
- Stuart A. Taylor (ORCID: https://orcid.org/0000-0002-6765-8806)
- Luca Marciani (ORCID: https://orcid.org/0000-0001-9092-4300)
- Moira A. Taylor (ORCID: https://orcid.org/0000-0003-4100-8343)
- Robert E. Spiller (ORCID: https://orcid.org/0000-0001-6371-4500)
- David Atkinson (ORCID: https://orcid.org/0000-0003-1124-6666)
- Faiz Alqarni
- Victoria Wilkinson‐Smith (ORCID: https://orcid.org/0000-0002-0878-1687)
- Hayfa Sharif (ORCID: https://orcid.org/0000-0003-0854-1242)
- Caroline L. Hoad (ORCID: https://orcid.org/0000-0001-5483-1027)
- Iyad Naim (ORCID: https://orcid.org/0000-0002-5077-8625)
- Maura Corsetti (ORCID: https://orcid.org/0000-0003-2957-4684)
- Guruprasad Padur Aithal (ORCID: https://orcid.org/0000-0003-3924-4830)
- Penny Anne Gowland (ORCID: https://orcid.org/0000-0002-4900-4817)
- Marc Alexander Benninga (ORCID: https://orcid.org/0000-0001-9406-9188)
- Soma Kumasaka (ORCID: https://orcid.org/0000-0001-5541-3847)
- S. Mark Scott (ORCID: https://orcid.org/0000-0002-7997-1533)
Institutions
- University of Nottingham (GB)
- Gunma University (JP)
- Queen Mary University of London (GB)
- King Saud Medical City (SA)
- Emma Kinderziekenhuis (NL)
- NIHR Nottingham Digestive Diseases Biomedical Research Unit (GB)
- Ministry of Health (KW)
- Agilent Technologies (United Kingdom) (GB)
- Nottingham Biomedical Research Centre (GB)
- University College London (GB)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1111/nmo.70215
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- King Saud University
- Medical Research Council
- NIHR Nottingham Biomedical Research Centre