Investigating the association between GLP-1 receptor agonists and mood disorders: A study integrating real-world data and Mendelian randomization
Both observational and MR analyses showed that patients treated with GLP-1 RAs may have no increased risk of emotional and behavioral disorders. Instead, genetic proxy activation of GLP-1 RAs may reduce the risk of anxiety, depression, and emotional lability.
Authors
- Rundong Lv (ORCID: https://orcid.org/0000-0002-9695-1745)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6052-0321)
- Ping Liu (ORCID: https://orcid.org/0000-0002-6152-4508)
- Xiulan Zheng (ORCID: https://orcid.org/0000-0002-1120-1583)
- Jie Pan (ORCID: https://orcid.org/0000-0002-9923-459X)
- Chen Feng (ORCID: https://orcid.org/0000-0002-3545-4817)
Institutions
- Macau University of Science and Technology (MO)
- University of Macau (MO)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- European Psychiatry
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1192/j.eurpsy.2025.10125
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cambridge
- U.S. Food and Drug Administration
- Wu Jieping Medical Foundation