Investigate the differences in executive functions and behavioral baseline indicators of Parkinson’s disease model mice based on the five - choice serial reaction time task
This study has successfully established a paradigm process and an evaluation baseline for touchscreen behavioral analysis in PD model mice. This provides an important basis for a deep understanding of the mechanisms of EFs impairment in PD patients, has potential guiding significance for the development of intervention strategies and treatment methods for EFs impairment in PD patients, and is expected to promote new progress in PD research in the field of neuroscience.
Authors
- Chuanxi Tang (ORCID: https://orcid.org/0000-0002-5500-8419)
- Zihan Liao (ORCID: https://orcid.org/0009-0006-7996-089X)
- Heng Gu (ORCID: https://orcid.org/0000-0001-8660-3010)
- Zhiyuan Liu (ORCID: https://orcid.org/0000-0002-4943-6572)
- Xinyu Liang (ORCID: https://orcid.org/0000-0003-0964-4294)
- Hong Pan (ORCID: https://orcid.org/0000-0002-0458-2613)
- Zihang Zhou (ORCID: https://orcid.org/0000-0003-2404-0720)
- Mengying Gu
Institutions
- Xuzhou Medical College (CN)
- Second People’s Hospital of Huai’an (CN)
Publication Details
- Journal
- Laboratory Animal Research
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s42826-025-00262-6
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00