Proton pencil beam scanning ultra‐high dose rate 3D lattice radiotherapy: A proof‐of‐concept FLASH SFRT study
Proton PBS UHDR 3D-LRT is achievable with the proposed two-field and single-field techniques, leveraging advanced inverse treatment planning and beam modifiers such as universal range shifters, beam-specific range compensators, apertures, and ridge filters. Planning study and end-to-end validation demonstrated that both techniques provided UHDR coverage to entrance normal tissues, favorable for triggering the FLASH effect, while maintaining high PVDR and plan robustness.
Authors
- Chanda Guha
- Nancy Y. Lee (ORCID: https://orcid.org/0000-0003-3044-9522)
- Pingfang Tsai (ORCID: https://orcid.org/0000-0003-3513-8256)
- Minglei Kang (ORCID: https://orcid.org/0000-0002-5054-7587)
- Xiaodong Wu (ORCID: https://orcid.org/0000-0001-8407-8398)
- Charles B. Simone (ORCID: https://orcid.org/0000-0002-0867-3694)
- Richard L. Bakst (ORCID: https://orcid.org/0000-0001-9279-7878)
- M. A. Vermeulen (ORCID: https://orcid.org/0000-0001-6353-4729)
- Arpit Chhabra (ORCID: https://orcid.org/0000-0001-7640-3381)
- Haibo Lin
- Hang Qi
- Xingyi Zhao (ORCID: https://orcid.org/0009-0008-9346-2760)
- Shouyi Wei
- Balaji Selvaraj (ORCID: https://orcid.org/0009-0009-2314-8423)
- J. Isabelle Choi (ORCID: https://orcid.org/0000-0003-0897-6668)
- Lee Xu
- Ajay Zheng
- Irini Yacoub
Institutions
- Albert Einstein College of Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Wisconsin–Madison (US)
- Stat Medical Devices (United States) (US)
- New York Proton Center (US)
- Medical Research Associates (US)
- Cancer Institute of Florida (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/mp.70187
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00