Expression and functional diversity of the glucagon-like peptide-1 receptor across tumor types
GLP-1R shows tissue-specific expression and prognostic relevance across cancer types. The low expression of GLP-1R across cancer types and the low frequency of genetic alterations suggest a limited direct role of GLP-1R mutations in cancer progression, but its variable expression may influence tumor behavior. Further research is needed to clarify both the functional role of GLP-1R in cancer biology and the safety and therapeutic potential of GLP-1R agonists in oncology.
Authors
- Wilson H. Lee (ORCID: https://orcid.org/0000-0001-5873-649X)
- Hagai Ligumsky (ORCID: https://orcid.org/0000-0002-5652-3703)
- Mario Alba (ORCID: https://orcid.org/0000-0002-0587-8790)
- Bangyan L. Stiles (ORCID: https://orcid.org/0000-0001-5480-2074)
- Zhipeng Lu (ORCID: https://orcid.org/0000-0001-5124-7546)
- Jerry Lee (ORCID: https://orcid.org/0000-0003-1515-0952)
Institutions
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- Tel Aviv Sourasky Medical Center (IL)
- Larry Ellison Foundation (US)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1007/s12672-025-04097-4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00