SRY mediates male-specific susceptibility to acute liver injury
Our results suggest that greater SRY expression in males may account for the susceptibility of males ALI. Dutasteride binds specifically to SRY and inhibits its expression, making it a promising therapy for the clinical treatment of ALI.
Authors
- Sheng Wei (ORCID: https://orcid.org/0000-0001-6888-6301)
- Lihong Dai (ORCID: https://orcid.org/0000-0003-3617-2691)
- Mengyun Ke (ORCID: https://orcid.org/0000-0002-2534-9669)
- Yi Lv (ORCID: https://orcid.org/0000-0003-3636-6664)
- Jian Dong (ORCID: https://orcid.org/0000-0001-6989-3829)
- Yi Fang (ORCID: https://orcid.org/0000-0001-7268-7751)
- Na Li (ORCID: https://orcid.org/0000-0002-0392-6672)
- Xiaogang Zhang (ORCID: https://orcid.org/0000-0002-6197-703X)
- Xu‐Feng Zhang (ORCID: https://orcid.org/0000-0002-4483-7326)
- Rongqian Wu (ORCID: https://orcid.org/0009-0009-5145-2326)
Institutions
- University of Pittsburgh (US)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s12964-025-02565-6
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00