UBL3 governs VEGFR inhibitor resistance by activating NOTCH signaling in renal cell carcinoma
This study emphasized the importance of UBL3 in VEGFRi resistance in RCC and proposed that UBL3 activated NOTCH signaling through two distinct pathways, thereby suppressing cancer apoptosis and promoting resistance to VEGFRis. These findings provided a solid scientific foundation and paved the way for the development of novel therapeutic strategies for patients with advanced RCC.
Authors
- Kun Fang (ORCID: https://orcid.org/0000-0003-3922-4434)
- Qingyang Lv (ORCID: https://orcid.org/0009-0006-0671-0988)
- Junkai Yang (ORCID: https://orcid.org/0000-0001-9147-5789)
- Wenjun Xiao (ORCID: https://orcid.org/0000-0002-6670-2203)
- Daojia Miao (ORCID: https://orcid.org/0000-0002-7780-1282)
- Jianlin Gong (ORCID: https://orcid.org/0000-0003-0910-014X)
- Hailong Ruan (ORCID: https://orcid.org/0009-0002-7164-5909)
- Yuzhong Ye (ORCID: https://orcid.org/0000-0003-1033-2482)
- Diaoyi Tan (ORCID: https://orcid.org/0009-0006-1896-9700)
- Chuanyi Zhao
- Xiaoping Zhang (ORCID: https://orcid.org/0000-0003-0218-3288)
- Zhiyong Xiong (ORCID: https://orcid.org/0000-0003-1894-7588)
- Jian Shi (ORCID: https://orcid.org/0000-0003-4115-8819)
- Feiyi Lu
- Songming Wu
Institutions
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.drup.2025.101332
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52