TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer
TSN inhibits FA DNA repair signaling in bladder cancer by suppressing JAK/STAT1-mediated FA core gene transcription, supporting its potential as a combinatorial agent to overcome cisplatin resistance.
Authors
- Zhiyuan Xie (ORCID: https://orcid.org/0000-0002-2952-5826)
- Wenqi Li (ORCID: https://orcid.org/0009-0007-0098-9698)
- Wenchao Zhao (ORCID: https://orcid.org/0009-0006-6871-7237)
- Liang Zhu (ORCID: https://orcid.org/0009-0009-4777-5341)
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Dose-Response
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/15593258251406039
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00