Liver Sinusoidal Endothelial Cells Promote Metabolic Dysfunction-associated Steatohepatitis Progression via Interleukin-1R1-mediated Chemokine Production Induced by Macrophage-derived Interleukin-1β
Macrophage-derived IL-1β promotes hepatic inflammation and fibrosis through IL1R1-dependent chemokine induction in LSECs, highlighting IL1R1 signaling as a therapeutic target in MASH.
Authors
- Daisuke Motooka (ORCID: https://orcid.org/0000-0002-4616-9608)
- Shogo Kobayashi (ORCID: https://orcid.org/0000-0002-8828-1067)
- Takahiro Kodama (ORCID: https://orcid.org/0000-0002-6250-1324)
- Yuta Myojin (ORCID: https://orcid.org/0000-0003-0360-9703)
- Yoshinobu Saito (ORCID: https://orcid.org/0000-0002-0624-0449)
- Katsuhiko Sato (ORCID: https://orcid.org/0000-0001-6288-9106)
- Kazuhiro Murai (ORCID: https://orcid.org/0000-0001-8634-2922)
- Yuki Tahata (ORCID: https://orcid.org/0000-0002-9116-7054)
- Yuki Makino (ORCID: https://orcid.org/0000-0002-2690-4548)
- Yōichi Sasaki (ORCID: https://orcid.org/0000-0002-0619-7970)
- Kenji Fukumoto
- Kazumasa Soma
- Hidetoshi Eguchi (ORCID: https://orcid.org/0000-0002-2318-1129)
- Hayato Hikita (ORCID: https://orcid.org/0000-0003-2488-7315)
- Sadatsugu Sakane (ORCID: https://orcid.org/0000-0002-6306-4621)
- Tomohide Tatsumi
- Tetsuo Takehara
- Seiya Kato (ORCID: https://orcid.org/0009-0005-9116-9729)
- Yoshiaki Kubota
Institutions
- Osaka University of Economics (JP)
- Keio University (JP)
- Osaka City University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101698
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64