Cross-sectional mediation analysis of systemic inflammation in the association between serum uric acid and diabetic kidney disease: Evidence from NHANES 1999–2018
Systemic inflammation, as measured by AISI, partially mediates the cross-sectional association between serum uric acid and diabetic kidney disease, supporting inflammation as one of several contributing pathways. The predictive performance of models incorporating AISI remains modest and does not outperform conventional clinical risk scores.
Authors
- Y.T. Cheng (ORCID: https://orcid.org/0000-0002-0200-6807)
- S Liu
- Wei Jing Liu (ORCID: https://orcid.org/0000-0002-5356-7057)
- Wei Li (ORCID: https://orcid.org/0000-0002-6329-198X)
- Jiaying Wang (ORCID: https://orcid.org/0000-0002-2580-0341)
- Jiaoyan Li (ORCID: https://orcid.org/0009-0000-0713-6101)
- Huiyue Feng
- Mengxiao Li
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Metabolism Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.metop.2025.100426
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00