Molecular glue neferine induces BAP31 homodimerisation to disrupt endoplasmic reticulum–mitochondria crosstalk for anti‐neuroinflammation in ischaemic stroke
In summary, our work reveals that BAP31 is a master regulator of ER-mitochondria communication during microglial activation and introduces a paradigm-shifting 'molecular glue' strategy for targeting ER-resident proteins. Additionally, these findings redefine the pharmacological landscape for modulating organelle interactions in microglia involved in neuroinflammatory diseases.
Authors
- Fang‐Fang Zhuo
- Bo Han (ORCID: https://orcid.org/0000-0002-6509-0313)
- Ya‐Xuan Zhu (ORCID: https://orcid.org/0000-0001-7545-5956)
- Z. M. Chen
- Ke‐Wu Zeng
- Yuhui Wang (ORCID: https://orcid.org/0000-0003-2936-3377)
- Hua Wang (ORCID: https://orcid.org/0000-0002-2605-5697)
- Ling Li (ORCID: https://orcid.org/0000-0002-1160-8914)
- Zhuo Yang (ORCID: https://orcid.org/0000-0002-5296-8596)
- Peng‐Fei Tu (ORCID: https://orcid.org/0000-0002-6487-1396)
- Zhengping Liu (ORCID: https://orcid.org/0000-0002-7944-2455)
- Tai Wei (ORCID: https://orcid.org/0000-0002-9629-0158)
- Wei Yu (ORCID: https://orcid.org/0000-0002-9672-3849)
Institutions
- Shihezi University (CN)
- Ministry of Education of the People's Republic of China (CN)
- Anhui Medical University (CN)
- Peking University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Shandong Academy of Pharmaceutical Sciences (CN)
- Ministry of Education (KN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1111/bph.70277
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province