Lycorine suppresses hepatocellular carcinoma via the reprogramming of myeloid and epithelial cells
Lycorine remodels the HCC TME through coordinated actions on malignant epithelial cells and immune populations, notably neutrophil and macrophage subpopulations. These findings support the potential development of lycorine-based combination therapies for HCC.
Authors
- Yafeng Liu (ORCID: https://orcid.org/0000-0003-3930-4872)
- Xinjun Hu (ORCID: https://orcid.org/0000-0003-1341-2971)
- Fuqiang Ma (ORCID: https://orcid.org/0000-0003-0447-0248)
- Juan Lu (ORCID: https://orcid.org/0000-0002-5508-0410)
- Wenjuan Chen (ORCID: https://orcid.org/0000-0001-7870-3564)
- Shujun J. Zhang (ORCID: https://orcid.org/0000-0001-6139-6887)
- Lele Zhang (ORCID: https://orcid.org/0009-0000-8519-1421)
- Lifan Zhang (ORCID: https://orcid.org/0000-0001-5182-3814)
- Xinyu Gu (ORCID: https://orcid.org/0009-0006-7019-5749)
Institutions
- Henan University of Science and Technology (CN)
- National Clinical Research (US)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.phymed.2025.157657
- Citations
- 1
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.94