Free-water imaging reveals cholinergic pathway damage in multiple system atrophy
Cholinergic pathway damage is a prominent pathological feature of MSA, with PPN-thalamus pathway showing particular vulnerability (as indicated by increased FWf) and strong clinical relevance. This FWf elevation likely related to neuronal degeneration or neuroinflammatory changes driven by α-synuclein pathology.
Authors
- Yao Wang (ORCID: https://orcid.org/0000-0002-4578-4932)
- Sushi Wang
- Weizheng Ran
- Ying Zhou (ORCID: https://orcid.org/0000-0002-4808-0500)
- Wenyang Tian
- Zhigang Chen (ORCID: https://orcid.org/0000-0002-9631-2599)
- Xinning Zhang (ORCID: https://orcid.org/0000-0002-3617-3582)
- Shan Ren (ORCID: https://orcid.org/0000-0001-9668-8249)
- Han Zhang (ORCID: https://orcid.org/0000-0002-6645-8810)
Institutions
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.nbd.2025.107213
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00