Hypericum perforatum L. extract alleviates metabolic-associated fatty liver disease through inflammation, lipid metabolism and ferroptosis modulation: a multi-omics perspective
GYJST exerts multi-target therapeutic effects against MAFLD by concurrently regulating ferroptosis, oxidative stress, lipid metabolism, and inflammation through interconnected mechanisms. These findings establish GYJST as a promising multi-target therapeutic candidate for MAFLD treatment.
Authors
- Jiancheng Wang (ORCID: https://orcid.org/0000-0001-9599-0171)
- Peng Huang (ORCID: https://orcid.org/0000-0001-9872-2834)
- Yidan Qin (ORCID: https://orcid.org/0000-0002-2576-1485)
- Jianguo Hu (ORCID: https://orcid.org/0000-0002-9832-6951)
- Jian Qin (ORCID: https://orcid.org/0000-0001-7113-555X)
- Yunling Zhu
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s13020-025-01248-1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00