CRISPR-Cas9-induced double-strand breaks disrupt maintenance of epigenetic information
This study underscores the importance of assessing and mitigating unintended epigenetic consequences in genome editing applications, as such changes can profoundly affect gene regulation and cellular function.
Authors
- Mengge Wang (ORCID: https://orcid.org/0000-0002-3673-1855)
- Chongwei Bi (ORCID: https://orcid.org/0000-0003-2108-1551)
- Mo Li (ORCID: https://orcid.org/0000-0003-0827-8907)
- Yingzi Zhang (ORCID: https://orcid.org/0000-0001-6871-5406)
Institutions
- King Abdullah University of Science and Technology (SA)
Publication Details
- Journal
- Genome biology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s13059-025-03851-9
- Citations
- 2
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 1.61