Immunoglobulin G4-Related Disease Masquerading as Crohn Disease, Managed by Intestinal Ultrasound: A Case Report
We present the case of a 36-year-old man initially diagnosed with Crohn disease who was nonresponsive to numerous advanced therapies. Further evaluation revealed diffuse lymphadenopathy, severe enterocolitis, and significantly elevated immunoglobulin G4 levels. Staining of colonic biopsies confirmed IgG4-related enterocolitis. Treatment with rituximab therapy and dose adjustment guided by clinical symptoms, stool calprotectin, and intestinal ultrasound resulted in symptomatic, endoscopic, histologic, and transmural healing.
Authors
- Noa Krugliak Cleveland (ORCID: https://orcid.org/0000-0003-1707-8560)
- Emma A. Picker
- Chase M. Duty (ORCID: https://orcid.org/0009-0000-0880-559X)
- Reem Jan (ORCID: https://orcid.org/0009-0003-8364-6789)
- Christopher R. Weber (ORCID: https://orcid.org/0000-0002-2117-3184)
- Khushi S. Bhondwe
Institutions
- University of Chicago (US)
Publication Details
- Journal
- Annals of Internal Medicine Clinical Cases
- Published
- 2025-12-01
- DOI
- https://doi.org/10.7326/aimcc.2025.0679
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00