Diffuse Large B-Cell Lymphoma Presenting as Aortic Aneurysm Rupture: A Case Report

We present a rare case of diffuse large B-cell lymphoma (DLBCL) mimicking an abdominal aortic aneurysm rupture. A 78-year-old male with prior endovascular aneurysm repair presented with abdominal pain, hypotension, and renal failure. Imaging revealed a periaortic mass concerning for aneurysm leak; however, PET/CT and biopsy confirmed DLBCL. This case underscores the diagnostic challenge posed by periaortic lymphoma masquerading as vascular emergencies. Clinicians should maintain a broad differential, as early recognition may avoid unnecessary surgery and enable appropriate oncologic management.

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Publication Details

Journal
Annals of Internal Medicine Clinical Cases
Published
2025-12-01
DOI
https://doi.org/10.7326/aimcc.2025.0892
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Diffuse Large B-Cell Lymphoma Presenting as Aortic Aneurysm Rupture: A Case Report

Elio Junior Feghali, Zubair Hassan, Edwin Feghali
Annals of Internal Medicine Clinical Cases
Lymphoma Diagnosis and Treatment
article

Diffuse Large B-Cell Lymphoma Presenting as Aortic Aneurysm Rupture: A Case Report

Elio Junior Feghali, Zubair Hassan, Edwin Feghali
article en

Abstract

We present a rare case of diffuse large B-cell lymphoma (DLBCL) mimicking an abdominal aortic aneurysm rupture. A 78-year-old male with prior endovascular aneurysm repair presented with abdominal pain, hypotension, and renal failure. Imaging revealed a periaortic mass concerning for aneurysm leak; however, PET/CT and biopsy confirmed DLBCL. This case underscores the diagnostic challenge posed by periaortic lymphoma masquerading as vascular emergencies. Clinicians should maintain a broad differential, as early recognition may avoid unnecessary surgery and enable appropriate oncologic management.

Annals of Internal Medicine Clinical CasesVol. 4(12)
Wichita State University (US), PRN of Kansas (US), Robert J. Dole VA Medical Center (US), Wichita Clinic (US)
Openalex Percentile: Top 48%
Lymphoma Diagnosis and Treatment
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Diffuse Large B-Cell Lymphoma Presenting as Aortic Aneurysm Rupture: A Case Report — Elio Junior Feghali, Zubair Hassan, et al. · Annals of Internal Medicine Clinical Cases (2025) | TGRS Research Map | TGRS