The CHPT-pSTAT3-SLC7A11 signaling axis controls progression and ferroptosis susceptibility of pancreatic cancer
The CHPT1-pSTAT3-SLC7A11 axis governs ferroptosis-dependent chemoresistance in PDAC. Dual targeting of CHPT1 and ferroptosis pathways represents a promising strategy to overcome GEM resistance, highlighting metabolic-kinase crosstalk as a therapeutic vulnerability.
Authors
- Zeyin Rong (ORCID: https://orcid.org/0000-0003-0005-2209)
- Qingcai Meng (ORCID: https://orcid.org/0000-0001-7433-3121)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-2605-8986)
- Jianhui Yang (ORCID: https://orcid.org/0000-0002-8710-1722)
- Zhen Tan (ORCID: https://orcid.org/0000-0002-6188-209X)
- Chen Liang (ORCID: https://orcid.org/0000-0003-0578-7589)
- Jie Hua (ORCID: https://orcid.org/0000-0002-0903-814X)
- Xianjun Yu (ORCID: https://orcid.org/0000-0002-6697-7143)
- Jin Xu (ORCID: https://orcid.org/0000-0001-6617-5311)
- Jiang Liu (ORCID: https://orcid.org/0009-0009-9957-9086)
- Miaoyan Wei
- Wei Wang (ORCID: https://orcid.org/0000-0003-2044-6387)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.tranon.2025.102624
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00