Physical and Cognitive Activities and Trajectories of AD Neuroimaging Biomarkers
Physical activity was associated with less synaptic dysfunction and cognitive activity with less synaptic dysfunction and lower amyloid burden over time, albeit effect sizes were small. Further research is needed to validate findings and clarify causal inference between physical and cognitive activities and AD neuroimaging biomarkers.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Jeremy A. Syrjanen (ORCID: https://orcid.org/0000-0001-5990-8206)
- Maria Vassilaki (ORCID: https://orcid.org/0000-0001-8328-136X)
- Alexander Wöll (ORCID: https://orcid.org/0000-0002-5736-2980)
- Eugene Scharf (ORCID: https://orcid.org/0000-0003-2928-3924)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Julie A. Fields (ORCID: https://orcid.org/0000-0002-1282-9866)
- Walter K. Kremers (ORCID: https://orcid.org/0000-0001-5714-3473)
- Yonas E. Geda (ORCID: https://orcid.org/0000-0003-1187-7230)
- Janina Krell‐Roesch (ORCID: https://orcid.org/0000-0003-4011-9842)
- Allison Hansen (ORCID: https://orcid.org/0000-0003-4866-8774)
- Susan B. Racette (ORCID: https://orcid.org/0000-0002-6932-1887)
Institutions
- Creighton University (US)
- Barrow Neurological Institute (US)
- Institute for Sports Medicine (DE)
- Mayo Clinic in Arizona (US)
- Institute of Sports Medicine and Science (JP)
- Mayo Clinic in Florida (US)
- Arizona State University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1212/wnl.0000000000214405
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00