Development of a Dynamic Counterfactual Risk Stratification Strategy for Newly Diagnosed Patients With AML Treated With Venetoclax and Azacitidine
The proposed ML strategy addresses a variety of RWD considerations and is readily tunable through coding and parameter updates for different contexts and use case needs. This strategy represents a novel approach to developing more effective RMs for AML and possibly other diseases.
Authors
- M. Ransom (ORCID: https://orcid.org/0009-0005-0347-162X)
- Udayan Mayur Kulkarni (ORCID: https://orcid.org/0009-0002-4909-9403)
- Michael Boyiadzis (ORCID: https://orcid.org/0000-0001-6699-6355)
- William Showers (ORCID: https://orcid.org/0000-0001-5989-8570)
- Justin Dale (ORCID: https://orcid.org/0009-0008-6879-9767)
- Nazmul Islam (ORCID: https://orcid.org/0009-0008-0609-7655)
- Krysta L. Engel (ORCID: https://orcid.org/0000-0003-3132-1491)
- Craig T. Jordan (ORCID: https://orcid.org/0000-0003-0869-3465)
- Brett M. Stevens (ORCID: https://orcid.org/0000-0002-9346-903X)
- Jamie S. Reuben (ORCID: https://orcid.org/0000-0002-5940-4224)
- Sarah E. Staggs
- Maura Gasparetto (ORCID: https://orcid.org/0009-0003-2129-7253)
- Jayesh Desai (ORCID: https://orcid.org/0000-0003-4246-9344)
- Clayton A. Smith (ORCID: https://orcid.org/0000-0001-6478-4244)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-7953-1159)
- Karan Sapiah (ORCID: https://orcid.org/0009-0006-0992-4033)
- Frank R. Markson (ORCID: https://orcid.org/0009-0005-4026-3838)
- Lezhou Wu
- James W. Coates (ORCID: https://orcid.org/0009-0007-9417-0762)
Institutions
- The Medical Center of Aurora (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- JCO Clinical Cancer Informatics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1200/cci-24-00308
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00