Effects and Mechanism of 2′-AMP on Renal Vascular Resistance
2'-AMP is a renal vasoconstrictor; however, TNAP, by metabolizing 2'-AMP to adenosine, protects against 2'-AMP-induced renal vasoconstriction. This protection is lost when TNAP activity is reduced. 2'-AMP-induced renal vasoconstriction involves positive allosteric modulation of P2X1Rs that enhances ATP-induced opening of P2X1R channels. R-IRI reduces kidney TNAP activity, and TNAP inhibition worsens R-IRI outcomes.
Authors
- Nahmah Kim‐Campbell (ORCID: https://orcid.org/0000-0002-5826-0388)
- Edwin K. Jackson (ORCID: https://orcid.org/0000-0002-8101-6009)
- Stevan P. Tofovic (ORCID: https://orcid.org/0000-0001-7663-2723)
- Delbert G. Gillespie
- Vladimir B. Ritov
- Dongmei Cheng (ORCID: https://orcid.org/0000-0002-4638-0884)
- Elizabeth V. Menshikova
- Zaichuan Mi
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1681/asn.0000000954
- Primary Topic
- Alkaline Phosphatase Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00