Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis
By upregulating SIRT3 expression to maintain mitochondrial homeostasis and suppress mtROS-NLRP3-mediated pyroptosis, HKL emerges as a promising therapeutic strategy for DN.
Authors
- Lingyu Du
- Maodong Liu
- Canghui Guo
- Tao Zhang (ORCID: https://orcid.org/0000-0002-4920-3963)
- Qian Wang (ORCID: https://orcid.org/0000-0002-7613-1408)
- Min Li (ORCID: https://orcid.org/0000-0002-3230-7678)
- Ying Li (ORCID: https://orcid.org/0000-0003-4012-6954)
- Ning Han (ORCID: https://orcid.org/0000-0002-8561-6626)
- Yanqing Chi
- Ke Yu
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s13098-025-02045-4
- Primary Topic
- Magnolia and Illicium research
- Type
- article
- Field-Weighted Citation Impact
- 0.00