Strategic trimodal therapy enhances radiation-induced abscopal response in renal cancer
This study presents a novel and effective strategy to induce the abscopal effect through a synergistic combination of targeted drug delivery, radiotherapy, and immunotherapy. The approach offers strong translational potential for improving radioimmunotherapy outcomes in renal and potentially other immunogenic cancers.
Authors
- Debabrata Mukhopadhyay (ORCID: https://orcid.org/0000-0002-3159-8928)
- Naga Malleswara Rao Nakka (ORCID: https://orcid.org/0009-0009-8360-1007)
- Enfeng Wang (ORCID: https://orcid.org/0009-0002-8676-3801)
- Shamit K. Dutta
- Krishnendu Pal (ORCID: https://orcid.org/0000-0002-4006-213X)
- Hari Krishnareddy Rachamala
Institutions
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12967-025-07518-8
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00