Orchestrating tumor-immune epigenetics via SERT–H3Q5ser axis
The serotonin transporter (SERT) and histone H3 serotonylation (H3Q5ser) integrate extracellular neurotransmitter signals to chromatin regulation in cancer. Here, we discuss how the SERT-H3Q5ser axis shapes tumor immunity and epigenetic plasticity, and highlight emerging strategies to therapeutically target this neuro-epigenetic interface.
Authors
- Canhui Cao (ORCID: https://orcid.org/0000-0002-7328-0264)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Trends in cancer
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.trecan.2025.11.004
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00