The evolving landscape of brain metastasis: volume II
Brain metastasis (BrM) represents the most common intracranial malignancy, arising in up to 30% of all adult cancer patients and contributing significantly to cancer-related morbidity and mortality. BrM is now recognized as a biologically distinct condition with unique mechanisms of organotropism, colonization, and therapeutic vulnerability. We highlight recent progress in omic and spatial profiling, which has revealed key drivers of brain tropism. These findings have reshaped therapeutic strategies, leading to clinical trials that specifically address central nervous system (CNS) involvement. Emerging approaches now include efforts to prevent brain relapse. Preclinical models increasingly provide sophisticated platforms to evaluate next-generation therapies. Collectively, these advances are transforming the clinical landscape, offering new hope for the prevention and management of BrM through precision medicine and integrated therapeutic strategies.
Authors
- Hussein A. Tawbi (ORCID: https://orcid.org/0000-0003-1942-851X)
- Johanna A. Joyce (ORCID: https://orcid.org/0000-0002-6332-2598)
- Frank Winkler (ORCID: https://orcid.org/0000-0003-4892-6104)
- Carey K. Anders (ORCID: https://orcid.org/0000-0001-9165-4074)
- Josh Neman (ORCID: https://orcid.org/0000-0002-6337-9615)
- Adrienne Boire
- Nuria Kotecki (ORCID: https://orcid.org/0000-0002-7753-230X)
- Srinivas Malladi (ORCID: https://orcid.org/0000-0002-0829-2365)
- Benjamin Izar
- Sanne B. Schagen (ORCID: https://orcid.org/0000-0003-0153-8059)
- Joan Massagué (ORCID: https://orcid.org/0000-0001-9324-8408)
- Manuel Valiente (ORCID: https://orcid.org/0000-0002-0647-7542)
- Matthias Preusser (ORCID: https://orcid.org/0000-0003-3541-2315)
- Gelareh Zadeh (ORCID: https://orcid.org/0000-0002-6637-4502)
- Nelson S. Moss (ORCID: https://orcid.org/0000-0002-0930-1681)
- Peter M. Siegel (ORCID: https://orcid.org/0000-0002-5568-6586)
- Varun Venkataramani (ORCID: https://orcid.org/0000-0002-2927-0886)
Institutions
- University of Southern California (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Columbia University Irving Medical Center (US)
- Institut Jules Bordet (BE)
- University Hospital Heidelberg (DE)
- The Netherlands Cancer Institute (NL)
- Spanish National Cancer Research Centre (ES)
- Southwestern Medical Center (US)
- Ludwig Cancer Research (CH)
- Mayo Clinic in Florida (US)
- Neurological Surgery (US)
- Southwestern Medical Center (US)
- Duke Cancer Institute
- McGill University (CA)
- Medical University of Vienna (AT)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Trends in cancer
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.trecan.2025.11.007
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52