Hepatitis E virus in immunocompromised children in Argentina: first report from a high-risk group
This study provides the first evidence of HEV exposure in immunosuppressed pediatric patients in Argentina, revealing a significantly higher seroprevalence compared to healthy peers. Although no active infections were detected, findings support the need for targeted HEV surveillance in high-risk pediatric groups, particularly in regions with confirmed zoonotic HEV circulation. Future multicenter, longitudinal studies are warranted to evaluate clinical outcomes and guide prevention strategies.
Authors
- Daniela Gardiol (ORCID: https://orcid.org/0000-0001-6392-4081)
- Guillermo Costaguta (ORCID: https://orcid.org/0000-0002-0468-5321)
- Ana Laura Cavatorta (ORCID: https://orcid.org/0000-0002-1414-369X)
- Julián Acosta (ORCID: https://orcid.org/0000-0001-6497-5454)
- Fernando Álvarez (ORCID: https://orcid.org/0000-0002-0534-5142)
Institutions
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Centro Científico Tecnólogico - Rosario (AR)
- Hospital Provincial de Rosario (AR)
- Instituto Cardiovascular de Rosario (AR)
- Instituto de Biología Molecular y Celular de Rosario (AR)
- Université Laval (CA)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12985-025-03037-6
- Primary Topic
- Hepatitis Viruses Studies and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00