Single-cell transcriptomic profiling reveals aberrant CD4⁺ naive T cell differentiation driving immune activation in Behçet’s uveitis
Our study reveals a coordinated mechanism linking systemic T cell dysregulation to localized ocular inflammation in BU. Targeting IL-32 and CXCR4 may represent promising strategies for restoring immune balance and preventing tissue damage in BU.
Authors
- Z. X. Meng
- Fuying Guo
- Yunfei Liu (ORCID: https://orcid.org/0000-0002-9362-3447)
- Dijie Qiao
- Xinyu Yao (ORCID: https://orcid.org/0000-0003-4554-5592)
- Lu Zhang (ORCID: https://orcid.org/0000-0002-2757-4173)
- Ziyu Du
- Cong Hu (ORCID: https://orcid.org/0000-0001-7934-142X)
- Chun Yan
- Yimeng Sun (ORCID: https://orcid.org/0000-0003-3557-6133)
- Wei Chi (ORCID: https://orcid.org/0000-0001-6487-002X)
Institutions
- Sun Yat-sen University (CN)
- Southern Medical University Shenzhen Hospital (CN)
- He Eye Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12967-025-07520-0
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.00