Effects of Porphyromonas gingivalis-derived lipopolysaccharide on the barrier function of cultured junctional epithelial cells
PG-LPS disrupts JE barrier function and alters its immunomodulatory properties, potentially contributing to periodontitis progression. These findings enhance our understanding of the underlying causes of periodontitis and inform targeted treatments to maintain JE defense against periodontopathogenic bacteria.
Authors
- Keisuke Tanaka (ORCID: https://orcid.org/0000-0003-0658-7781)
- Daisuke Saito (ORCID: https://orcid.org/0000-0003-3012-1607)
- Ryo Aizawa (ORCID: https://orcid.org/0009-0007-5621-3581)
- Junichi Tanaka (ORCID: https://orcid.org/0000-0003-3286-0972)
- Kazunori Okada (ORCID: https://orcid.org/0000-0001-7321-7911)
- Masayo Sunaga (ORCID: https://orcid.org/0000-0002-1090-8632)
- Marika Sugano
- Kenji Mishima (ORCID: https://orcid.org/0000-0001-8927-9105)
- Matsuo Yamamoto
Institutions
- SHOWA Medical University (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.job.2025.100721
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00