Investigating insulin’s role in regulating local aromatase in growth plate development
In this study, we found a significant increase in the expression of insulin receptors, indicating that insulin signaling regulates aromatase expression, thereby affecting epiphyseal growth plate development. However, the molecular mechanisms by which insulin receptors regulate aromatase expression remain unclear.
Authors
- Lingyan Qiao (ORCID: https://orcid.org/0000-0003-0865-9304)
- Yao Dong (ORCID: https://orcid.org/0000-0001-8883-5384)
- Minmin Xue (ORCID: https://orcid.org/0000-0002-6629-6436)
- Sicui Hu (ORCID: https://orcid.org/0000-0002-2631-0117)
- Cheng Li (ORCID: https://orcid.org/0000-0002-7381-4940)
- Rongxiu Zheng
Institutions
- Qingdao University (CN)
- Tianjin Medical University General Hospital (CN)
- Qingdao Eighth People's Hospital (CN)
- Pingjin Hospital (CN)
- Qingdao Women and Children's Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1371/journal.pone.0337215
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00