MRI-defined high-risk rectal cancer patients: comparison of treatment response and survival outcomes between total neoadjuvant therapy and neoadjuvant chemoradiotherapy—a propensity score matched analysis
In MRI-defined high-risk LARC patients, TNT could improve the survival trend while increasing the likelihood of organ preservation without exacerbating surgical complexity. These findings emphasize the fact that TNT should be prioritized for the high-risk MRI-defined population to achieve enhanced local tumor control, sustained therapeutic efficacy, and prolonged survival.
Authors
- Meng Zhao (ORCID: https://orcid.org/0000-0002-2813-1112)
- Yajia Gu (ORCID: https://orcid.org/0000-0001-5831-5214)
- Yaqi Wang (ORCID: https://orcid.org/0000-0002-8003-6251)
- Rong Li (ORCID: https://orcid.org/0000-0002-9830-2765)
- Zhiyuan Zhang (ORCID: https://orcid.org/0000-0001-9067-0670)
- Yiqun Sun (ORCID: https://orcid.org/0000-0002-3375-3012)
- Qi Zhou (ORCID: https://orcid.org/0000-0002-6549-9362)
- Tong Tong (ORCID: https://orcid.org/0000-0002-9180-8181)
- Ruiting Li (ORCID: https://orcid.org/0000-0001-8041-1050)
- Fan Xia (ORCID: https://orcid.org/0000-0001-8185-8663)
- Qiong Ma
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-6740-6441)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- International Journal of Colorectal Disease
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1007/s00384-025-05044-z
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China