Eczema Coxsackium: An Unusual Presentation in Atopic Dermatitis and Hand, Foot, and Mouth Disease

Eczema coxsackium, a more severe manifestation of hand, foot, and mouth disease, is primarily caused by coxsackievirus A6 and A16. It predominantly affects children with atopic dermatitis and is characterized by vesicular, bullous, and erosive eruptions on both active and inactive eczematous skin, including involvement of the oral mucosa, typically following a brief febrile prodrome. We report an atypical case of eczema coxsackium in an 8-month-old with a history of atopic dermatitis who presented with a widespread rash and prolonged fevers without typical oral lesions. The diagnosis of eczema coxsackium was made based on clinical findings and history. This illustrative case underscores the importance of considering eczema coxsackium in the differential diagnosis of viral exanthems, particularly in children with atopic dermatitis.