GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma

GFER is essential for mitochondrial redox balance and suppressing tumor immunogenicity in pancreatic tumors, with the combination of GFER inhibition with immune checkpoint blockade resulting in a strong antitumor response.

Authors

Institutions

Publication Details

Journal
Cancer Research
Published
2025-12-02
DOI
https://doi.org/10.1158/0008-5472.can-24-4211
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma

Melinda Soeung, Francesca Citron, Wantong Yao, Er-Yen Yen et al.
Cancer Research
interferon and immune responses
article

GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma

Melinda Soeung, Francesca Citron, Wantong Yao, Er-Yen Yen, Charles A. Dyke, Sisi Gao, Giulio Draetta, Johnathon L. Rose, Guangchun Han, Rutvi Shah, Giannicola Genovese, Ziheng Chen, Linghua Wang, Hyuk Jean Kwon, I-Lin Ho, Ningping Feng, Jintan Liu, Andrea Viale, Shan Jiang, Haoqiang Ying, Xinmiao Yan, Sanjana Srinivasan, Shaojun Zhang, Huamin Wang, Qing Chang, Sara Sainani
article en

Abstract

GFER is essential for mitochondrial redox balance and suppressing tumor immunogenicity in pancreatic tumors, with the combination of GFER inhibition with immune checkpoint blockade resulting in a strong antitumor response.

Cancer ResearchVol. 86(5)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US), The University of Texas MD Anderson Cancer Center (US), Dana-Farber Cancer Institute (US)
Openalex Percentile: Top 57%
interferon and immune responses
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.