GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma
GFER is essential for mitochondrial redox balance and suppressing tumor immunogenicity in pancreatic tumors, with the combination of GFER inhibition with immune checkpoint blockade resulting in a strong antitumor response.
Authors
- Melinda Soeung
- Francesca Citron (ORCID: https://orcid.org/0000-0002-5896-3008)
- Wantong Yao (ORCID: https://orcid.org/0000-0002-0172-7530)
- Er-Yen Yen (ORCID: https://orcid.org/0000-0003-2918-5419)
- Charles A. Dyke (ORCID: https://orcid.org/0009-0007-5431-5445)
- Sisi Gao (ORCID: https://orcid.org/0000-0002-4809-1699)
- Giulio Draetta (ORCID: https://orcid.org/0000-0001-5225-9610)
- Johnathon L. Rose (ORCID: https://orcid.org/0000-0003-1687-5103)
- Guangchun Han (ORCID: https://orcid.org/0000-0001-9277-2507)
- Rutvi Shah (ORCID: https://orcid.org/0000-0002-2382-9175)
- Giannicola Genovese (ORCID: https://orcid.org/0000-0003-1392-9954)
- Ziheng Chen (ORCID: https://orcid.org/0000-0003-1918-106X)
- Linghua Wang (ORCID: https://orcid.org/0000-0001-9380-0266)
- Hyuk Jean Kwon (ORCID: https://orcid.org/0009-0000-7055-0014)
- I-Lin Ho (ORCID: https://orcid.org/0000-0002-8914-710X)
- Ningping Feng (ORCID: https://orcid.org/0000-0003-1917-9648)
- Jintan Liu (ORCID: https://orcid.org/0000-0001-6609-9777)
- Andrea Viale (ORCID: https://orcid.org/0000-0003-4328-1044)
- Shan Jiang (ORCID: https://orcid.org/0000-0002-2042-5298)
- Haoqiang Ying (ORCID: https://orcid.org/0000-0003-0616-2310)
- Xinmiao Yan (ORCID: https://orcid.org/0000-0002-9749-1621)
- Sanjana Srinivasan
- Shaojun Zhang (ORCID: https://orcid.org/0000-0001-5760-5797)
- Huamin Wang (ORCID: https://orcid.org/0000-0002-2038-5863)
- Qing Chang (ORCID: https://orcid.org/0009-0001-5301-2625)
- Sara Sainani (ORCID: https://orcid.org/0009-0004-3975-6267)
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- The University of Texas MD Anderson Cancer Center (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4211
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00