Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in <i>EGFR</i> -Mutant Lung Cancer
Pharmacological blockade of nanotube-mediated mitochondrial transfer between tumor cells and RGS5+MYL9+ fibroblasts effectively overcome tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer, offering a clinically applicable strategy to enhance EGFR inhibitor efficacy.
Authors
- J Li (ORCID: https://orcid.org/0009-0000-0310-3898)
- Qinglin Wang (ORCID: https://orcid.org/0000-0003-0876-8551)
- Wenjia Xia (ORCID: https://orcid.org/0000-0001-9208-0973)
- Fanchen Meng (ORCID: https://orcid.org/0000-0002-9773-1728)
- Ziyang Shen (ORCID: https://orcid.org/0000-0002-6923-8338)
- Zhijun Xia (ORCID: https://orcid.org/0009-0009-0949-5656)
- Zhao-Tao Li (ORCID: https://orcid.org/0009-0003-6049-0005)
- Tongyan Liu (ORCID: https://orcid.org/0000-0001-5677-4513)
- Qinhong Sun (ORCID: https://orcid.org/0009-0007-1321-201X)
- Shiyi Huang (ORCID: https://orcid.org/0009-0002-0534-7794)
- Rong Yin (ORCID: https://orcid.org/0000-0002-9744-4251)
- Jing Tan (ORCID: https://orcid.org/0000-0002-5595-777X)
- Youtao Xu (ORCID: https://orcid.org/0000-0002-6999-4870)
Institutions
- Xuzhou Medical College (CN)
- Jiangsu Cancer Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0433
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52