Photocatalytic Hydro-Fluorosulfonylation of Thioalkynes via Shuttle HAT
Reported herein is a photocatalytic hydro-fluorosulfonylation of thioalkynes to access FSO<sub>2</sub>-substituted vinyl sulfides with broad substrate scope and high stereoselectivity. Our straightforward approach proceeds via a shuttle hydrogen atom transfer (HAT) sequence, effectively suppressing the competing atom transfer radical addition (ATRA) pathway. The resulting vinyl sulfonyl fluorides serve as versatile synthetic hubs for various downstream transformations, as well as potent antifungal agents against plant pathogens.
Authors
- Qingyuan Feng (ORCID: https://orcid.org/0009-0002-1230-5234)
- Meizhong Tang
- Tianyu He (ORCID: https://orcid.org/0000-0002-9427-6694)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-1638-7751)
- Shenlin Huang (ORCID: https://orcid.org/0000-0001-7322-6981)
- Qian Liu (ORCID: https://orcid.org/0009-0000-1479-1657)
Institutions
- Yunnan Normal University (CN)
- Nanjing Forestry University (CN)
- Institute of Chemical Industry of Forest Products (CN)
- Chinese Academy of Forestry (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1021/acs.orglett.5c04543
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00