Molecular subtype-driven disparities in intraoperative touch imprint cytology accuracy for sentinel lymph node assessment in clinically node-positive breast cancer treated with neoadjuvant chemotherapy
Collectively, our study demonstrates that ITPC exhibits a robust accuracy for detecting SLN metastases in cN + breast cancer patients treated with NAC. The findings support the implementation of molecular subtype-specific SLN management: ITPC alone may be adequate for HER2-positive and TNBC tumors; for hormone receptor-positive (Luminal) subtypes, ITPC may need to be combined with molecular/immunohistochemical analysis.
Authors
- Di Shi (ORCID: https://orcid.org/0000-0002-4894-732X)
- Bo Ping
- Ying Chen (ORCID: https://orcid.org/0000-0003-2607-3489)
- Yanli Wang (ORCID: https://orcid.org/0000-0002-7576-3235)
- Bing Chen (ORCID: https://orcid.org/0000-0002-0988-9534)
- Wentao Yang (ORCID: https://orcid.org/0000-0002-4496-0631)
- Fei Ren (ORCID: https://orcid.org/0000-0003-4100-8845)
- Xiaochun Wan (ORCID: https://orcid.org/0000-0003-3745-1860)
- Ping Wei
- Hao Zhang (ORCID: https://orcid.org/0009-0006-9483-834X)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Anhui Medical University (CN)
- Fudan University Shanghai Cancer Center (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s40001-025-03569-1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00