Targeting CXCL8 alleviates intestinal epithelial inflammation by suppressing the JAK-STAT pathway
This study revealed that CXCL8 aggravated inflammation in small intestinal epithelial cells by activating the JAK-STAT pathway. Silencing CXCL8 alleviated LPS-induced inflammation and improved cell survival, which were reversed by STAT1 overexpression. These results highlighted the CXCL8-JAK-STAT axis as a potential therapeutic target for treating IBDs such as Crohn's disease.
Authors
- Biqin Chen
- Jintao Jiang
- Junmin Xu (ORCID: https://orcid.org/0000-0001-7878-2004)
- Zengjie Chi
- Jian Wu (ORCID: https://orcid.org/0000-0002-2333-1000)
- Xurui Sun
- Xiaolong Wu (ORCID: https://orcid.org/0009-0004-4273-4974)
Institutions
- Deyang Stomatological Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s40001-025-03602-3
- Citations
- 1
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.05