Unbound free fatty acids from intralipid displace bilirubin from albumin, comparable to sulfisoxazole
Raises clinical concern about the safety of Intralipid administration in vulnerable neonates, particularly preterm infants with impaired bilirubin clearance and reduced albumin binding capacity and suggests that lipid therapy protocols in the NICU may inadvertently increase kernicterus risk, calling for careful evaluation of dosing, timing, and monitoring.
Authors
- Alan M. Kleinfeld (ORCID: https://orcid.org/0000-0003-1313-4369)
- Thomas Hegyi (ORCID: https://orcid.org/0000-0001-9919-1043)
- Andrew H. Huber (ORCID: https://orcid.org/0000-0001-6207-6148)
- William Oh (ORCID: https://orcid.org/0000-0001-5113-8147)
Institutions
- Brown University (US)
- Johnson University (US)
- Torrey Pines Institute For Molecular Studies (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1038/s41390-025-04673-y
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00