Minocycline partially reverses established PTSD-related behavioral traits in rats exposed to repetitive low-level blast injury
These studies have implications for understanding the nature of blast-induced behavioral traits, some of which may be the direct result of inflammatory effects, while others may be independent of inflammation or if the result of inflammation, not reversible once downstream structural or neurochemical changes are established.
Authors
- Gregory A. Elder (ORCID: https://orcid.org/0000-0001-7035-8380)
- Stephen T. Ahlers
- Rania Abutarboush
- Carlos A. Toro (ORCID: https://orcid.org/0000-0002-7355-7534)
- Rita De Gasperi (ORCID: https://orcid.org/0000-0002-5281-4263)
- Miguel A. Gama Sosa (ORCID: https://orcid.org/0000-0003-1064-4451)
- Patrick R. Hof (ORCID: https://orcid.org/0000-0002-3208-1154)
- Carolyn W. Zhu (ORCID: https://orcid.org/0000-0002-2318-715X)
- Usmah Kawoos
- Georgina Pérez Garcia
- Gissel M. Perez
Institutions
- Henry M. Jackson Foundation (US)
- Naval Medical Research Command (US)
- Allen Institute for Brain Science (US)
- James J. Peters VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fneur.2025.1666737
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Office of Research and Development
- Rehabilitation Research and Development Service
- National Institute on Aging