Molecular and genetic innovations: Breaking barriers in Solanaceae stress resilience

• Genomic and molecular tools are accelerating Solanaceae crop improvement. • Review emphasizes genome editing and omics in stress resilience breeding. • Big data, AI, and systems biology enhance trait discovery and prediction. • Integration of genomic resources aids development of climate-resilient varieties. • Strategic roadmap presented for translating molecular insights into practice. Horticultural crops belonging to the Solanaceae family play an immense role in addressing global food security demands, particularly in response to abrupt climate change driven by overpopulation and, to some extent, resource limitations. In this regard, exploring the integrated effects of crop genomics and molecular breeding techniques is crucial for developing climate-resilient varieties with high yields and productivity. The primary focus of this review is to highlight the innovative approaches, current status, and prospects of Solanaceae crops in strengthening their functional genomics foundation with scientific evidence. Herein, we discuss the underlying science of genomic resources, including diverse genotypes, reference genomes, omics tools, and molecular breeding strategies for selecting the most suitable genomes and implementing genome editing in horticultural crops. The application of these strategies in Solanaceae crops can facilitate the development of novel varieties with desirable traits such as disease resistance, abiotic stress tolerance, and improved nutritional quality. Moreover, we emphasize the functional role of big data analysis, artificial intelligence, and systems biology in harnessing key genomic data from horticultural crops. The review also explores emerging trends and future perspectives on Solanaceaecrops, focusing on translating genomic discoveries into high-yielding varieties. The sustainable enhancement of such varieties featuring climate resilience and disease resistance, will be vital in ensuring food safety and security for an increasingly populated world.