Synergistic effect of oxaliplatin and nanocurcumin in dendrosomal carrier to inhibits ovarian cancer cells invasion and metastasis through the long non-coding RNA MEG3
These results suggest that MEG3 knockdown impairs the anti-metastatic properties of DNC and OXA by modulating MMP-2 and MMP-9 expression. The combination of DNC and OXA holds promise as an effective therapeutic strategy in OC, and MEG3 may serve as a potential biomarker and therapeutic target, particularly in drug-resistant ovarian cancer.
Authors
- Elahe Seyed Hosseini (ORCID: https://orcid.org/0000-0001-9382-0822)
- Hamed Haddad Kashani (ORCID: https://orcid.org/0000-0003-2606-2886)
- Hossein Nikzad (ORCID: https://orcid.org/0000-0002-5735-0162)
- Zahra Shabani (ORCID: https://orcid.org/0000-0003-4995-3024)
- Marziyeh Alizadeh Zarei
Institutions
- Hamedan University of Medical Sciences (IR)
- Kashan University of Medical Sciences (IR)
Publication Details
- Journal
- Current Research in Pharmacology and Drug Discovery
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.crphar.2025.100243
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00