Local Interactions Between Innate Immune Signaling, Microbiota, and Bile Acids Drive the Development of Duodenal Adenomas
Bile acids and the microbiota are necessary for duodenal adenoma development and are potentially modifiable risk factors in humans at risk of duodenal adenomas. The recruitment of myeloid cells may promote tumor progression via the release of reactive oxygen species.
Authors
- Stephen H. Barnes (ORCID: https://orcid.org/0000-0001-6837-1674)
- María T. Abreu (ORCID: https://orcid.org/0000-0002-7294-0574)
- Irina Fernández (ORCID: https://orcid.org/0000-0002-0184-0744)
- Hajar Hazime (ORCID: https://orcid.org/0000-0002-9759-9034)
- Eddy E. Gonzalez-Horta (ORCID: https://orcid.org/0000-0003-2043-7552)
- Gillian E. Jacobsen (ORCID: https://orcid.org/0000-0001-7647-6062)
- Judith Pignac-Kobinger (ORCID: https://orcid.org/0000-0001-5842-4488)
- Júlia Fritsch
- Nivis Brito
- Juan F. Burgueño
- Trevor Cickovski
- Landon Wilson
- Yuguang Ban (ORCID: https://orcid.org/0000-0002-2874-0647)
- Ana M. Santander (ORCID: https://orcid.org/0000-0003-1781-8549)
- Haby Dione
- Lily Wang (ORCID: https://orcid.org/0000-0002-6630-8767)
- Zhen Gao (ORCID: https://orcid.org/0000-0002-5655-020X)
- Mark S. Sundrud
Institutions
- Dartmouth College (US)
- Dartmouth Institute for Health Policy and Clinical Practice (US)
- Cedars-Sinai Medical Center (US)
- Florida International University (US)
- University of Alabama at Birmingham (US)
- University of Miami Health System (US)
- Dartmouth Psychiatric Research Center (US)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101694
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00