Apparent diffusion coefficient increases during short course radiotherapy in rectal tumours: Results from a multicentre longitudinal trial
ADC changes during short course radiotherapy were detectable in 56% of the patients. Furthermore, the limited ADC variation across DWI sequences supports feasibility of multicentre investigations of MRI-linac based DWI. These findings encourage future research linking ADC to clinical outcomes in rectal cancer for potential treatment personalization.
Authors
- Uulke A. van der Heide (ORCID: https://orcid.org/0000-0002-4146-6419)
- Doenja M. J. Lambregts (ORCID: https://orcid.org/0000-0003-2990-0099)
- Anne Louise Højmark Bisgaard (ORCID: https://orcid.org/0000-0002-5402-0045)
- Faisal Mahmood (ORCID: https://orcid.org/0000-0002-7270-7967)
- Martijn Intven (ORCID: https://orcid.org/0000-0002-5068-5517)
- Gert J. Meijer (ORCID: https://orcid.org/0000-0001-7275-319X)
- Pètra M. Braam (ORCID: https://orcid.org/0000-0003-2354-6834)
- Alice M. Couwenberg (ORCID: https://orcid.org/0000-0002-3547-1895)
- M.E.P. Philippens (ORCID: https://orcid.org/0000-0003-0205-3459)
- Petra J. van Houdt (ORCID: https://orcid.org/0000-0001-7431-8386)
- Chavelli M. Kensen (ORCID: https://orcid.org/0000-0001-9161-6852)
- Erik van der Bijl (ORCID: https://orcid.org/0000-0001-7663-4390)
Institutions
- Radboud University Nijmegen (NL)
- University of Southern Denmark (DK)
- Utrecht University (NL)
- Odense University Hospital (DK)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- Physics and Imaging in Radiation Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.phro.2025.100880
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Odense Universitetshospital