Red blood cell–derived transglutaminase 2 influences thrombus formation
TG2 activity within RBCs plays a specific role in modulating EV formation, which in turn influences the fibrin structure and spatial distribution within blood clots. Absence of TG2 activity leads to more EV formation, promoting faster thrombin generation and clot formation, suggesting a regulatory role for TG2 in coagulation kinetics.
Authors
- Rienk Nieuwland (ORCID: https://orcid.org/0000-0002-5671-3400)
- Hanke L. Matlung
- Robin van Bruggen (ORCID: https://orcid.org/0000-0002-1676-0720)
- Judith J. de Vries (ORCID: https://orcid.org/0000-0002-5007-2147)
- Chi M. Hau (ORCID: https://orcid.org/0000-0002-0404-8517)
- Naoual Ouazzani Chahdi (ORCID: https://orcid.org/0009-0004-7753-9087)
- H. Eyisoylu
- Joost C. M. Meijers
- Moniek P.M. de Maat
Institutions
- Erasmus MC (NL)
- Sanquin (NL)
- Amsterdam Neuroscience (NL)
- Synapse (Netherlands) (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.rpth.2025.103274
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00