Efficacy and safety of atezolizumab plus bevacizumab in MSI-like metastatic colorectal cancer: a multicenter, single-arm, phase II, open-label clinical trial
MSI-like GES does not identify a population with higher sensitivity to immune checkpoint plus angiogenesis inhibition. However, responses are promising in patients with MSI tumors and, to a lesser extent, in patients without liver metastasis regardless of MSI status.
Authors
- Sanne C.F.A. Huijberts (ORCID: https://orcid.org/0000-0002-8144-1419)
- Erika Martinelli (ORCID: https://orcid.org/0000-0002-0291-475X)
- Alena Gros (ORCID: https://orcid.org/0000-0002-1207-1880)
- Adriano Piris (ORCID: https://orcid.org/0000-0003-1081-9821)
- Josep M. Tabernero (ORCID: https://orcid.org/0000-0002-2495-8139)
- René Bernards (ORCID: https://orcid.org/0000-0001-8677-3423)
- Élena Elez (ORCID: https://orcid.org/0000-0002-4653-6324)
- Salvatore Siena (ORCID: https://orcid.org/0000-0002-2681-2846)
- Fortunato Ciardello
- Ramón Salazar (ORCID: https://orcid.org/0000-0001-9419-6232)
- Sabrina Arena (ORCID: https://orcid.org/0000-0002-1318-2494)
- A. Sartore-Bianchi
- Vı́ctor Moreno (ORCID: https://orcid.org/0000-0002-2818-5487)
- Susana Muñoz (ORCID: https://orcid.org/0000-0003-0543-8100)
- Neeltje Steeghs (ORCID: https://orcid.org/0000-0003-2989-2279)
- Susana Roselló (ORCID: https://orcid.org/0000-0003-3915-4130)
- Édison Francisco Viveros Chavarría (ORCID: https://orcid.org/0000-0003-0610-4110)
- Gaetan de Schaetzen
- Javier Ros (ORCID: https://orcid.org/0000-0002-8137-5415)
- Ramón Alemany (ORCID: https://orcid.org/0000-0001-8660-550X)
- Rodrigo Dienstmann (ORCID: https://orcid.org/0000-0001-5997-318X)
- B Wilmsen
- Andrés Cervantes (ORCID: https://orcid.org/0000-0003-3806-3691)
- Sabine Tejpar
- A. Bardelli
- Cristina Santos
- E García-Galera
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Hebron University (PS)
- Universitat de València (ES)
- University of Campania "Luigi Vanvitelli" (IT)
- Universitair Ziekenhuis Leuven (BE)
- Bellvitge University Hospital (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Vall d'Hebron Institut de Recerca (ES)
- Institut Català d'Oncologia (ES)
- Oncode Institute (NL)
- European Organisation for Research and Treatment of Cancer (BE)
- Cancer Genomics Centre (NL)
- Vall d'Hebron Hospital Universitari (ES)
- Torino e-district (IT)
- Candiolo Cancer Institute (IT)
- INCLIVA Health Research Institute (ES)
- Vall d'Hebron Institute of Oncology (ES)
- University of Turin (IT)
- KU Leuven (BE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105892
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00