IGF-II-secreting bladder tumour presenting as a fall in a 91-year-old

Unexplained and recurrent episodes of hypoglycaemia should raise clinical suspicion of a paraneoplastic process that requires further investigation. It is important to maintain a broad range of differentials when approaching a frail patient with recurrent hypoglycaemia. Management should be guided by discussion with a multidisciplinary team and patient preference. IGF-II-secreting tumours are widely associated with mesenchymal tumours; however, this case presents a rare possible association with bladder tumours. Surgical resection of NICTH tumours is the mainstay of treatment, but when it is not feasible, other medical management should be explored.

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Publication Details

Journal
Endocrinology Diabetes and Metabolism Case Reports
Published
2025-10-01
DOI
https://doi.org/10.1530/edm-25-0090
Primary Topic
Growth Hormone and Insulin-like Growth Factors
Type
article
Field-Weighted Citation Impact
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article

IGF-II-secreting bladder tumour presenting as a fall in a 91-year-old

Shwetha Sairam, Imaan Hirji, Hiro Khoshnaw
Endocrinology Diabetes and Metabolism Case Reports
Growth Hormone and Insulin-like Growth Factors
article

IGF-II-secreting bladder tumour presenting as a fall in a 91-year-old

Shwetha Sairam, Imaan Hirji, Hiro Khoshnaw
article en

Abstract

Unexplained and recurrent episodes of hypoglycaemia should raise clinical suspicion of a paraneoplastic process that requires further investigation. It is important to maintain a broad range of differentials when approaching a frail patient with recurrent hypoglycaemia. Management should be guided by discussion with a multidisciplinary team and patient preference. IGF-II-secreting tumours are widely associated with mesenchymal tumours; however, this case presents a rare possible association with bladder tumours. Surgical resection of NICTH tumours is the mainstay of treatment, but when it is not feasible, other medical management should be explored.

Endocrinology Diabetes and Metabolism Case ReportsVol. 2025(4)
Royal Surrey NHS Foundation Trust (GB)
Openalex Percentile: Top 50%
Growth Hormone and Insulin-like Growth Factors
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