Metabolic signatures in osteoporotic cancellous bone: a comprehensive dual-platform metabolomic analysis
This study provides the first comprehensive metabolomic profile of human osteoporotic cancellous bone, highlighting a network of metabolic disturbances that underlie dysregulated bone remodeling. These findings identify amino acid, purine, and phospholipid pathways as potential mechanistic drivers and therapeutic targets in osteoporosis. Metabolites with strong statistical significance warrant further validation and translational investigation.
Authors
- Qingyun Xie (ORCID: https://orcid.org/0009-0003-1621-7589)
- Mengyuan He (ORCID: https://orcid.org/0000-0002-9892-4337)
- Jun Sheng (ORCID: https://orcid.org/0000-0001-8786-2137)
- Yingchao Tang
- Huey Chieng Tan (ORCID: https://orcid.org/0000-0001-8337-8452)
- Jianxiang Long
- D. Joshua Liao (ORCID: https://orcid.org/0000-0003-3904-349X)
- Da Liu (ORCID: https://orcid.org/0000-0003-3994-2786)
- Wei Wang (ORCID: https://orcid.org/0000-0002-1431-8971)
- Song Chen (ORCID: https://orcid.org/0000-0002-2505-7930)
- Shihong Li (ORCID: https://orcid.org/0000-0003-1302-9761)
Institutions
- First People's Hospital of Chongqing (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12891-025-09368-3
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81