Prophylactic isoimperatorin protects against LPS-ALI via mTOR-dependent control of inflammation, oxidative stress and ferroptosis markers
ISO protected against LPS-induced ALI under a prophylactic dosing protocol via mTOR-dependent signaling (predominantly mTORC1), thereby restraining inflammation, oxidative stress, and ferroptosis-related markers. These findings support ISO as a mechanistically informed prophylactic lead that warrants evaluation under post-insult therapeutic regimens.
Authors
- Weiru Liu (ORCID: https://orcid.org/0000-0001-8356-1361)
- Danna Wang
- Tianqi Cui
- Zhiqun Xing
- Jia Ke
- Zhen Cui (ORCID: https://orcid.org/0000-0002-6639-153X)
- Jiecheng Zhang (ORCID: https://orcid.org/0000-0001-9731-3983)
- Liang Yin (ORCID: https://orcid.org/0000-0003-4745-9196)
- Tingting Chen (ORCID: https://orcid.org/0009-0006-9485-6740)
- Ziyi Zhang (ORCID: https://orcid.org/0000-0001-7563-5236)
- Qīng Wáng (ORCID: https://orcid.org/0000-0003-3997-6767)
- Jiayu Li (ORCID: https://orcid.org/0000-0002-3480-9006)
- Li Xu (ORCID: https://orcid.org/0000-0001-6875-9396)
- Chenlu Ma
- Wenjun Zhao (ORCID: https://orcid.org/0000-0002-8579-3155)
- Xiaoying Yang (ORCID: https://orcid.org/0000-0001-8382-9719)
- Yinliang Zhang
- Min Qiu (ORCID: https://orcid.org/0000-0002-8650-0510)
- Xi Tang
- Haojie Zuo
- Xiaoqin Wu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Xuzhou Medical College (CN)
- Wenzhou Medical University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Shandong Provincial Hospital (CN)
- Zhejiang Taizhou Hospital (CN)
- Shandong First Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.jep.2025.120998
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52